Evolution of RAG transposon unveiled
نویسندگان
چکیده
منابع مشابه
Evidence of G.O.D.’s Miracle: Unearthing a RAG Transposon
Diversity of antibodies and T cell receptors is generated by gene rearrangement dependent on RAG1 and RAG2, enzymes predicted to have been derived from a transposable element (TE) that invaded an immunoglobulin superfamily gene early in the evolution of jawed vertebrates. Now, Huang et al. report the discovery of ProtoRAG in the lower chordate Amphioxus, the long-anticipated TE related to the R...
متن کاملDiscovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination
Co-option of RAG1 and RAG2 for antigen receptor gene assembly by V(D)J recombination was a crucial event in the evolution of jawed vertebrate adaptive immunity. RAG1/2 are proposed to have arisen from a transposable element, but definitive evidence for this is lacking. Here, we report the discovery of ProtoRAG, a DNA transposon family from lancelets, the most basal extant chordates. A typical P...
متن کاملStructural evolution of calcite at high temperatures: Phase V unveiled
The calcite form of calcium carbonate CaCO₃ undergoes a reversible phase transition between Rc and Rm at ~1240 K under a CO₂ atmosphere of ~0.4 MPa. The joint probability density function obtained from the single-crystal X-ray diffraction data revealed that the oxygen triangles of the CO₃ group in the high temperature form (Phase V) do not sit still at specified positions in the space group Rm,...
متن کاملEvolution of RAG-1 in polyploid clawed frogs.
Possible genetic fates of a gene duplicate are silencing, redundancy, subfunctionalization, or novel function. These different fates can be realized at the DNA, RNA, or protein level, and their genetic determinants are poorly understood. We explored molecular evolution of duplicated RAG-1 genes in African clawed frogs (Xenopus and Silurana) (1) to examine the fate of paralogs of this gene at th...
متن کاملMajor transitions in dinoflagellate evolution unveiled by phylotranscriptomics.
Dinoflagellates are key species in marine environments, but they remain poorly understood in part because of their large, complex genomes, unique molecular biology, and unresolved in-group relationships. We created a taxonomically representative dataset of dinoflagellate transcriptomes and used this to infer a strongly supported phylogeny to map major morphological and molecular transitions in ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science China Life Sciences
سال: 2016
ISSN: 1674-7305,1869-1889
DOI: 10.1007/s11427-016-5107-5